Maybe.  According to Reuters actor John Krasinski (Jim from The Office) is on a list of potential candidates to play the Marvel superhero.  He wouldn't be my first choice, but then again I thought Robert Downey would not make a good Tony Stark...boy was I wrong on that one.  They are looking for an American to play the character (which makes sense) otherwise I'd go with Sam Worthington (Avatar, Clash of the Titans), but he's a Brit, I think.  After seeing the Borne movies I think Matt Damon would be good in the role.  But they might be looking for someone younger (and maybe not such a superstar).  Personally I think they should go with an unknown.  My fave choice there would be Ryan Coughlin (Farmhouse, Lake Dead).